Evaluation of Serum Alanine aminotransferase, Aspartateaminotransferase and Alkaline phosphatase in Adult ObeseNinava People.

Abstract

Oral contraceptive steroids are used by an estimated 60 to 70 million women world­wide. Over the past 20 years there have been both case reports and clinical studies on the topic of drug interactions with these agents. The use of oral contraceptives has been consistently associated with decreased levels of the activity of many enzymes, and Vitamin C. The main transpo1ter of copper, a2-globulin ceruloplasmin which is a multifunctional enzyme. The present study was conducted in Family planqing in Tikril Teaching r Iospital in Tikrit province, Serum ceruloplasmin, copper, vitamin C, and iron levels were estimated in 40 women who were using oral contraceptives for at least I year and 40 women who were using copper T(Intrauterine contraceptive device). The mean age of women was (33.08 years).Forty non- contraceptive users participated in the study as a control group. They were drawn from the same population and matched for age with the contraceptive-users group. The serum level of ceruloplasmin (Cp) as antioxidant protein was significantly higher in women were using oral contraceptive than control group (60±0.16 mg/ell vs. 36.5±0.96 mg/dl, P<0.05) while the <lifference between the serum (Cp) in control and women using copper T is statically non significant P<0.05, also mean of serum copper in women were using contraceptive (18±0.612 µM/L) is significantly higher (P<0.01) than the mean of control (11.2±0.474 µM/L), while the difference between the serum copper in control and women using copper T is statically non signi ficant(P<O.O 1 ). On the other hand the serum vitamin C values in women using oral contraceptives and copper T(5.57±0.02 , 6±0.031 LM/L respectively) were significantly lower than control group(l 0.73± 0.09 µM/L, P<0.05.