Effects of chronic myeloid leukemia on some haematological parameters and indicators during chemotherapy period

Abstract

This study include calculation of some haematological parameters & indicators of chronic myeloid leukemia(CML) after chemotherapy, involve collecting (40) blood samples from CML patients & (40) blood samples from normal individuals considered as control group with ages of (35-60) year; after making the haematological testes of these samples we noticed the presence of variable significant differences(p<0.05) in the values, by which at the beginning of the treatment by chemotherapy there was obvious decreasing in all hemoglobin value (9.8±0.61)gm/100 ml ,the number of red blood cells (3.88±0.30) millions cells /mm3 & packed cell volume (40.7±2.57)% and decreasing of blood indices like MCV (80.4+2.13) fl, MCH (24.1±1.32) pg, MCHC (30.1±1.13)g/dl, and this decreasing continue throughout chemotherapy period, we also found obvious increasing in leukocytes and platelets numbers at the beginning of the treatment by chemotherapy (7765±665.1) cell/mm3 (396.6±41.2) cell/mm3 respectively, after that decreasing of these numbers throughout chemotherapy (7350 70)cell/mm3 of leukocytes. In addition to that we observe increasing in erythrocyte sedimentation rate(19.6±8.82)mm/1h ,and increasing in granular white blood cells like neutrophils cells (74.3±6.91)%, eosinophils cells(8.25±2.19)% and basophils cells (3.55±0.99)% of leukemia patients in comparison with control group