Association of Dyslipidemia, Atherogenic Index and some Biochemical Markers with Cardiovascular Risk in Postmenopausal Women

Abstract

Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women around the world.

Objectives: To identify the link between dyslipidemia, atherogenic index and some other biochemical parameters in postmenopausal women.

Materials and Methods: all participants of women aged from 53-70 years. A total 60 postmenopausal women have cardiovascular diseases and 30 healthy women participants enrolled in the present study as a control group. Blood samples were collected are prepared and for assessment of lipid profile, myosin and renal function tests. 

Results: Mean Cholesterol levels were significantly increased in the CVD group compared to controls (207.7 ± 20.4mg\dl vs control 173.8 ± 21.0 mg\dl). Similarly, triglycerides concentrations were markedly higher in the CVD group (207.6 ± 74.2mg\dl) vs control group (167.6 ± 21.8mg\dl), as were LDL level in CVD group (149.6 ± 20.7mg\dl) vs control group (97.9 ± 21.0mg\dl). While HDL level was significantly reduced in CVD group (22.2 ± 10.4mg\dl) vs control group (48.4 ± 7.8mg\dl). VLDL level show higher level in CVD group (41.6 ± 15.1mg\dl) vs control group (33.5 ± 4.3mg\dl). Atherogenic index (CVD: 1.0 ± 0.3 vs. control: 0.5 ± 0.1), while cardiac risk observed (CVD: 10.6 ± 3.2 VS. 3.6 ± 0.7). Myosin level between groups (CVD: 2289.8±1087.6pg\ml vs. control: 2943.1±2326.2pg\ml; p value >0.05). Mean urea levels were significantly increased in the CVD group compared to controls group (44.1 ± 9.6mg\dl) vs control (33.9 ± 7.4mg\dl). Similarly, creatinine level was significantly higher in CVD group (1.750 ± 0.760mg\dl) vs (0.452 ± 0.02mg\dl).

Conclusions: In postmenopausal women cardiovascular risk rises as obesity increased, lipid profile, atherogenic index and aging may lead to renal function disturbance and increase level of urea and creatinine.