Evaluation of serum lipid in diabetic patients on differenttypes of treatment

Abstract

Diabetes mellitus is chronic metabolic disorder which causes many complications. These are subdivided into microvascular complication affecting retina, kidney and peripheral nerves and macrovascular complications (atherosclerosis) affecting the major arterial systems including coronary arteries. Abnormal lipid metabolism is common in DM and it play an important role in the macrovascular complications. In this case control study 150 diabetic patients on different regimens of treatment were investigated for hyperlipidemia and compared to each other and to 50 apparently healthy control. Comparison of each group of diabetic patients with the control group was as follow; regarding total cholesterol there was no significant difference, higlyceride was significantly higher in group 2 (mixed insulin and oral hypoglycemic therapy), and group 3 (oral hypoglycemic drugs therapy) (P<0.001) in comparison with control group, while in group I (only insulin therapy) it was lower than the control group, but the difference was siatistically not significant, HDL was significantly lower in all groups in comparison with control group and the least value of HDL was found in group 3 (P<0.001). Regarding LDL there was no significant difference in comparison with the control group, while VLDL was higher in group 2 and 3 than the control group and the difference was significant (P<0.001). Comparison of the measured parameters among three groups of diabetic patients was as follow; regarding total cholesterol and LDL there was no significant difference among these three groups. Triglycerides and VLDL were significantly lower in group 1 (P<0.001), while HDL was significantly lower in group 3 (P< 0.001). Cholesterol, triglycerides and VLDL were significantly higher in females in group 2 (P<0.05). Regarding HDL and LDL no significant difference was found between males and females. In group I triglyceride was higher in those with 5 - l0 years treatment, while in group 2 & 3 there was no significant difference in measured parameters regarding the duration of treatment