Embryo toxicity of pefloxacin in mice

Abstract

Fluoroquinolones are extremely useful agents and an important therapeutic advance. Each fluoroquinolones tends produce characteristic adverse effects. Different studies showed that there was evidence about adverse effects of some :fluoroquinolones as levofloxacin, alatrofloxacin, trovaflxacin and moxifloxacin on the pregnant experimental lab. Animals when they were administered higher than the maximum recommended human doses , the current study was conducted to highlight the effects of different dosages of pefloxacin on the pregnant mice .The study revealed that the litter size and weight of bi1th were unaffected at the recommended oral human doses. Also reflects that there were little effects on body weight gain of dams when the dose exceeds the maximum recommended human dosage. No teratogenic effects were observed even at high oral doses. This project needs further investigation using different lab. Animals with large sample size.