Assessment of IL-12 and Liver Enzymes Levels in Serum of Some Iraqi Patients with Colon Cancer

Authors

  • Zainab Ahmed Ismail Department of Biology, Science College, Tikrit University
  • Mohanad Hasan Mahmood Al-Izzi Department of Biology, Science College, Tikrit University

DOI:

https://doi.org/10.25130/tjphs.2025.19.1.3.30.40

Keywords:

Colon cancer, Interleukin-12, AST, ALT, ALP, Iraq

Abstract

Background: Interleukin-12 has extensively studied in colorectal cancer, but its correlation with liver enzymes is still limit.

Objective: the present study aimed to assess the serum levels of Interleukin-12 and liver enzymes in Iraqi patients with colon cancer.

Methods: Serum samples (90) were collected divided to 50 samples of colorectal cancer CRC patients and 40 of healthy subjects, interleukin-12 was measured using ELISA, while liver enzymes were measured spectrophotometrically and statistically analyzed.

Results:  The study showed significant increase (P˂0.0001) in concentration of IL-12 (304.6±26.91) pg/ml, ALP (309.9±66.84) IU/L, AST (323.5±109.9) IU/L and ALT (37.4±7.78) IU/L compared to healthy subjects (142.3±14.71 pg/ml, 165.5±38.8 IU/L, 152.6±55.34 IU/L, and 18.28±6.14 IU/L) respectively for all biomarkers. .

Conclusion: Iraqi patients with CRC show elevated serum IL-12 and elevated lever enzymes, however, liver enzymes work independently and not affected by IL-12.

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Published

2025-06-30

How to Cite

1.
Ismail ZA, Al-Izzi MHM. Assessment of IL-12 and Liver Enzymes Levels in Serum of Some Iraqi Patients with Colon Cancer. Tikrit J. Pharm. Sci. [Internet]. 2025 Jun. 30 [cited 2025 Aug. 8];19(1):30-4. Available from: https://tjphs.tu.edu.iq/index.php/j/article/view/571

Issue

Vol. 19 No. 1 (2025): Tikrit Journal of Pharmaceutical Sciences

Section

Articles

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Copyright (c) 2025 THIS IS AN OPEN ACCESS ARTICLE UNDER THE CC BY LICENSE http://creativecommons.org/licenses/by/4.0/

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