Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations

المؤلفون

  • Qabas Naji Rashid
  • Mohsin Hamza Bakir
  • Shirwan Omar Baban

DOI:

https://doi.org/10.25130/tjphs.2013.11.1.7.67.77

الملخص

A simple, rapid and sensitive spectrophotometric method for determination of methyldopa (MD) using 4-chloro-7-nitrobenzo-2-oxa-1, 3-diazole (NBD-Cl) as reagent in an alkaline medium (pH 12.3). Absorbance of the resulting brown-colored product is measured at 470 nm. Beer’s Law is obeyed in a concentration range of (1.6-17.6 µg/mL) with molar absorptivity (1.9337×104 L/mol.cm), correlation coefficient 0.9988, and the limit of detection (5.536×10-3 µg/mL). The method has been successfully applied to the determination of Methyldopa in pharmaceutical preparations.

التنزيلات

منشور

2023-04-24

كيفية الاقتباس

1.
Naji Rashid Q, Hamza Bakir M, Omar Baban S. Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations. Tikrit J. Pharm. Sci. [انترنت]. 24 أبريل، 2023 [وثق 2 أبريل، 2025];11(1):67-7. موجود في: https://tjphs.tu.edu.iq/index.php/j/article/view/312