Evaluation of aldose reductase levels and some other biochemical variables in patients with type 2 diabetes

Abstract

Background: Diabetes is a disease characterized by high blood sugar levels. This elevation occurs as a result of the body's inability to produce insulin or use glucose effectively, resulting in the presence of high glucose in the blood.

Objective: The current study aimed to measure the activity of the aldose reductase enzyme in addition to other biochemical variables, including adiponectin, lipoproteins type (a) in the blood of patients with type 2 diabetes compared to the control group.

Methods: The study included collecting 90 blood samples from both sexes, patient’s blood samples were (60), including (33) females and (27) samples were males from people with type 2 diabetes, whose ages ranged between (18-75) years, and (30) blood samples from healthy people as a control group the patients were diagnosed under the supervision of specialist doctors at Al-Sharqat General Hospital- Iraq.

Results: The results showed a significant increase (P<0.05) in the level of aldose reductase, adiponectin, and lipoproteins -a  compared to the control group.

Conclusion: Increased concentrations of both adiponectin and lipoprotein-a in diabetic patients recognized the preventive effect of both against atherosclerotic alterations and increased risk of cardiovascular disease.