Synthesis and study the biological activity of some six, five and fused ring heteroatome systems derived from 2-mercapto benzothiazole

Abstract

In this paper ,new series of 2-hydrazino benzothiazole [1], 2-N-benzothiazole-N`-phenyl hydrazine carboxamide [2], 2-N-[(3)-N`-phenyl-5-(p-bromophenyl)-2`-hydroxy-1,3-oxazolin-2`-yl] benzothiazol hydrazine [3] , 2-N-benzothiazole-N`-1-naphthyl hydrazine carboxamide [4], 2-N-[(3`)-N`-(1-naphthyl)-5`-(p-bromo phenyl)-2`-hydroxy-1,3-oxazolin-2`-yl)] benzothiazol hydrazine [5], of 2-thiaacetic acid benzothiazole [6] ,2-thiaacetyl chloride benzothiazole [7], 5-amino-2-mercapto-1,3,4-thiadiazole [8], of 2-mercapto-[5-acetamid thiamethyl benzothiazol]-1,3,4-thiadiazole [9], 2-phenyl-5-chloromethyl-1,3,4-oxadiazole [10],and 2-[5-phenyl-1,3,4-oxadiazol-2`-thiomethyl] benzothiazole [11] have been synthesized. These compounds were characterized by FT-IR , spectrum, elemental analysis and the melting points were checked the purity of the prepared compounds was determined by TLC technique. The biological activity was also studied against Proteus vulgaris (G-) and Staphylococcus aureus (G+) with different concentrations.