Spectrophotometric Assay ofMetoclopramide in PharmaceuticalPreparations

Abstract

A sinple and sensitive photometric rnethod for the trace determination of metoclopramide lras been worked olri .The rnethod is based on the diazotization reaction of the detet'tnination in acidic medium with the coupled o,-naphthol,to form purplisli violet water soiubie azo dye that shows maximurn absorption at 549nm with molir absorbtivity of 3.85x104 l.mol-l.cm-l.Bee.'s larv is obeyed over the concentration range 12.5-200pg of metoclopramide in final volume of 25m1,i.e.0.5-8pprn with the relative enor of -0.2 - +1.3 atrd a relative standard deviation 0.68-2.17%.Morever,the method does not require either temperature